Coronary Artery Bypass

It is well known that Coronary Artery Bypass Graft (CABG) failure in the long term is mainly due to restenosis, which can be related to sub-optimal haemodynamical conditions near the grafts.

Under this assumption, the research at MOX aims to a better understanding of CABG effects on coronary circulation and possibly to the improvement of long term surgery success. In particular we want to characterize fluid-dynamic quantities of clinical interest in different patient-specific configurations and study the sensitivity of the haemodynamics with respect to physical parameters and geometrical features (stenoses severity or grafting angles).

In our studies we couple patient-specific clinical data, a parametrized formulation and reduced order models allowing a comparison of the outcomes of different surgical interventions (e.g. grafting angles) or disease (e.g. stenoses severity) at greatly reduced computational costs.

Clinical Partner:  Cardio-surgery and Radiology Divisions of Sacco Hospital, Milan, Italy.


  1. Guerciotti B., Vergara C., Ippolito S., Quarteroni A., Antona C., Scrofani R., Computational study of the risk of restenosis in coronary bypassesBiomechanics and Modeling in Mechanobiology. DOI:10.1007/s10237-016-0818-x
  2. F. Ballarin, E.Faggiano, S.Ippolito, A.Manzoni, A.Quarteroni, G.Rozza, R.Scrofani, Fast simulations of patient specific haemodynamics of coronary artery bypass grafts based on a POD Galerkin method and a vascular shape parametrization, J.Comput.Physics, to appear, 2015



  1. R. Ferrero – Numerical study of the fluid-dynamics in patient-specific coronary artery bypass grafts – MSc in Mathematical Engeneering, Politecnico di Torino – Advisors: L. Preziosi, A. Quarteroni, E. Faggiano – A.Y. ’12-’13
  2. F. Ballarin – Reduced-order models for patient-specific haemodynamics of coronary artery bypass grafts – Ph.D in Mathematical
    Models and Methods in Engineering, Dipartimento di Matematica, Politecnico di Milano, 2015