Isogeometric approximation of cardiac electrophysiology models on surfaces: an accuracy study with application to the human left atrium

40/2015

Isogeometric approximation of cardiac electrophysiology models on surfaces: an accuracy study with application to the human left atrium

Monday 24th August 2015

Patelli, A.S.; Dedè, L.; Lassila, T.; Bartezzaghi, A.; Quarteroni, A.

We consider Isogeometric Analysis in the framework of the Galerkin method for the spatial approximation of cardiac electrophysiology models defined on NURBS surfaces; specifically, we perform a numerical comparison between basis functions of degree p ? 1 and globally C^k-continuous, with k = 0 or p ? 1, to find the most accurate approximation of a propagating front with the minimal number of degrees of freedom.We show that B-spline basis functions of degree p ? 1, which are C^(p?1)-continuous capture accurately the front velocity of the transmembrane potential even with moderately refined meshes; similarly, we show that,for accurate tracking of curved fronts, high-order continuous B-spline basis functions should be used. Finally, we apply Isogeometric Analysis to an idealized human left atrial geometry described by NURBS with physiologically sound fiber directions and anisotropic conductivity tensor to demonstrate that the numerical scheme retains its favorable approximation properties also in a more realistic setting. Keywords: Isogeometric Analysis, cardiac electrophysiology, surface PDEs, high-order approximation