Controlled release with finite dissolution rate

Controlled release with finite dissolution rate
Tuesday 20th April 2010
Biscari, Paolo; Minisini, Sara; Pierotti, Dario; Verzini, Gianmaria; Zunino, Paolo
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We consider a two-phase generalization of the classical Higuchi’s model for controlled drug release. The drug is assumed to be prepared in a drug eluting stent in its solid phase by immersion in a polymeric matrix which eventually delivers the drug when it reaches the free end. We derive a single effective evolution equation, which we prove to be equivalent to the original system of two coupled PDE’s. We provide analytical estimates for the asymptotic regimes of large and small diffusion. Results from numerical simulations allow then to fill up the gap, and understand the behavior of the system in intermediate regimes.