Distant supervision for imaging-based cancer sub-typing in Intrahepatic Cholangiocarcinoma

Keywords

Statistics
Health Analytics
Code:
17/2023
Title:
Distant supervision for imaging-based cancer sub-typing in Intrahepatic Cholangiocarcinoma
Date:
Friday 24th February 2023
Author(s):
Savin, M.S.; Cavinato, L.; Costa, G.; Fiz, F.; Torzilli, G.; Vigano', L.; Ieva, F.
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Abstract:
Finding effective ways to perform cancer sub-typing is currently a trending research topic for therapy optimization and personalized medicine. Stemming from genomic field, several algorithms have been proposed. In the context of texture analysis, limited efforts have been attempted, yet imaging information is known to entail useful knowledge for clinical practice. We propose a distant supervision model for imaging-based cancer sub-typing in Intrahepatic Cholangiocarcinoma patients. A clinically informed stratification of patients is built and homogeneous groups of patients are characterized in terms of survival probabilities, qualitative cancer variables and radiomic feature description. Moreover, the contributions of the information derived from the ICC area and from the peritumoral area are evaluated. The findings suggest the reliability of the proposed model in the context of cancer research and testify the importance of accounting for data coming from both the tumour and the tumour-tissue interface.
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Savino, M. S., Cavinato, L., Costa, G., Fiz, F., Torzilli, G., Viganò, L., & Ieva, F. (2022, July). Distant supervision for imaging-based cancer sub-typing in Intrahepatic Cholangiocarcinoma. In 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC) (pp. 1032-1035). IEEE.