Longitudinal Latent Overall Toxicity (LOTox) profiles in osteosarcoma: a new taxonomy based on latent Markov models
Tuesday 25th October 2022
Spreafico, M.; Ieva, F.; Fiocco, M.
Due to the presence of multiple types of adverse events with different levels of severity, the analysis of longitudinal toxicity data is a difficult task in cancer studies. In this work, a novel approach based on latent Markov models and compositional data techniques is proposed. The latent status of interest is the Latent Overall Toxicity (LOTox) condition of each patient. The main objectives are to identify different latent states of overall toxicity burden and to investigate the evolution of individual toxicity risk during cancer treatment. This methodology is applied to osteosarcoma treatment data to provide novel techniques that may support medical decisions in childhood cancer therapy.