A Mesoscale Computational Model for Microvascular Oxygen Transfer
Keywords
Living Systems and Precision Medicine
Code:
86/2021
Title:
A Mesoscale Computational Model for Microvascular Oxygen Transfer
Date:
Thursday 16th December 2021
Author(s):
Possenti, L.; Cicchetti, A.; Rosati, R.; Cerroni, D.; Costantino, M.L.; Rancati, T.; Zunino, P.
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Abstract:
We address a mathematical model for oxygen transfer in the microcirculation. The model includes blood flow and hematocrit transport coupled with the interstitial flow, oxygen transport in the blood and the tissue, including capillary-tissue exchange effects. Moreover, the model is suited to handle arbitrarily complex vascular geometries. The purpose of this study is the validation of the model with respect to classical solutions and the further demonstration of its adequacy to describe the heterogeneity of oxygenation in the tissue microenvironment. Finally, we discuss the importance of these effects in the treatment of cancer using radiotherapy.
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Possenti, L., Cicchetti, A., Rosati, R., Cerroni, D., Costantino, M.L., Rancati, T., Zunino, P. A Mesoscale Computational Model for Microvascular Oxygen Transfer (2021) Annals of Biomedical Engineering, .
Possenti, L., Cicchetti, A., Rosati, R., Cerroni, D., Costantino, M.L., Rancati, T., Zunino, P. A Mesoscale Computational Model for Microvascular Oxygen Transfer (2021) Annals of Biomedical Engineering, .