A mechanochemical instability drives vertebrate gastrulation

 
Speaker:
Mattia Serra
Affiliation:
University of California, San Diego
When:
Tuesday 14th December 2021
Time:
14:30:00
Where:
Live: Aula Consiglio, VII piano, Dip. di Matematica
Online: https://mox.polimi.it/mox-seminars/?id_evento=2101
Link to seminar:
Link to conference will become active five minutes before due starting time: Click HERE to refresh page
To access use a supported browser.
Abstract:
Gastrulation is a critical event in vertebrate morphogenesis, characterized by coordinated large-scale multi-cellular movements. One grand challenge in modern biology is understanding how spatio-temporal morphological structures emerge from cellular processes in a developing organism and vary across vertebrates. We derive a theoretical framework that couples tissue flows, stress-dependent myosin activity, and actomyosin cable orientation. Our model, consisting of a set of nonlinear coupled PDEs, predicts the onset and development of observed experimental patterns of wild-type and perturbations of chick gastrulation as a spontaneous instability of a uniform state. We use analysis and numerics to show how our model recapitulates the phase space of gastrulation morphologies seen across vertebrates, consistent with experiments. Altogether, this suggests that early embryonic self-organization follows from a minimal predictive theory of active mechano-sensitive flows. https://www.biorxiv.org/content/10.1101/2021.10.03.462928v2 Contatto: pasquale.ciarletta@polimi.it
PDF: