Biomechanical modeling of the heart, and cardiovascular system - From sarcomeres to organ / system, with experimental assessments and patient-specific clinical validations

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Computational Medicine for the Cardiocirculatory System
Dominique Chapelle
M3DISIM, INRIA - Paris - France
Thursday 7th June 2018
Aula Consiglio VII Piano - Edificio 14, Dipartimento di Matematica POLITECNICO DI MILANO
Cardiac contraction originates at a subcellular - molecular, indeed - scale, within specific components of the cardiomyocytes (i.e. cardiac cells) called sarcomeres. This contractile behaviour then needs to be integrated at the organ level, namely, with a specific structure and shape. Furthermore, this organ crucially interacts with other physiological systems, the first of which being blood circulation via the cardiac function itself, and also the nervous system that controls the heart via various regulation mechanisms, and these interactions must be adequately represented in order to obtain accurate and predictive model simulations. This presentation will provide an overview of the recent advances on cardiac modeling achieved in the M3DISIM group, with a particular focus on the key multiscale, multi-physics and integrated system modeling aspects that need to be addressed, with many associated challenges pertaining to numerical methods and model validation, in particular. Contact:
Dominique Chapelle is a senior researcher at Inria - in the M3DISIM research team also affiliated with Ecole Polytechnique - and the head of science of the Inria Saclay-Ile-de-France research center. He graduated from Ecole Polytechnique, MIT, and Paris 6 University, with a dual background in applied mathematics and engineering. His areas of expertise are in mechanical modeling and numerical analysis, with a focus on cardiac modeling developed over the past 15 years