1-2-3-4: a story about whole genome duplications in fish and other vertebrates

Frédéric Brunet

Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon

Friday 15th January 2016

16:00:00

Aula Seminari Saleri VI Piano Dipartimento di Matematica-MOX, Politecnico di Milano

Gene and genome duplications, which increase gene copy number at different scales, are considered to be important contributors to the evolution of organisms. During the evolution of vertebrates, two successive rounds of whole genome duplication, called 1R and 2R have highly influenced the organization of gene content of genomes. After WGDs, genomes returned progressively to a diploid state, but a certain amount of genes were kept as duplicates, which led to the formation and extension of many gene families. A fish-specific genome duplication called 3R occurred at the base of the teleost fish lineage. A fourth round of WGD has also been characterized in the Salmonidae. Examples of gene family expansion in vertebrates will be presented. contact: laura.sangalli@polimi.it