SACMS - Stability Analysis and Control Mechanisms of Seizures

The goal of the SACMS project is to advance the understanding of seizure dynamics and potential therapeutic strategies through mathematical modelling, simulation and optimal control. Specifically, we will develop differential models to study epilepsy and analyze the influence of changes in neurotransmitter/ionic species concentrations on pathophysiological brain function, which is still poorly understood. The SACMS project’s primary objective includes conducting a bifurcation analysis to study the effect of High-Frequency Oscillations (HFOs) on brain stability and quantifying the influence of ionic instability on seizures. Bridging neuroscience with nonlinear dynamics is expected to significantly benefit brain function research and modelling.