Mechanistic computational modelling of radiation damage to microvasculature and of its effect on tumour microenvironment
Project information
MOX responsible
Paolo Zunino
Start date
January 2019
End date
December 2023
Abstract
We hypothesize that irradiation affects the TME characteristics, in particular the microvasculature, that sustain tumour growth and sensitivity to RT. To test this hypothesis, we will adopt a multi-modal approach: advanced in vitro experiments coupled to computational modelling and in-vivo clinical evaluation.