Models, Simulation, Uncertainty, and Medicine - Numerical Methods in Computational Biomechanics and Cardiology

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High Performance Computing
Computational Medicine for the Cardiocirculatory System
Rolf Krause
Center for Computational Medicine in Cardiology, Università della Svizzera italiana,
Thursday 22nd February 2018
Aula Consiglio VII Piano - Edificio 14, Dipartimento di Matematica POLITECNICO DI MILANO
The numerical simulation of physiological and biomechanics processes allows for a better understanding of many internal mechanism of the human body. For example stresses in joints or the activation sequence of the human heart can be computed “in silico”, thus providing the possibility to develop new therapies or to assist physician in diagnosis and therapy. In order to get close to realistic medical applications, or even to a clinical setting, several difficulties have to be addressed. These contain the efficient simulation of coupled and non-linear partial differential equations, the choice of the appropriate models, and, last but not least, the personalization of the simulation by means of, e.g., parameter fitting or uncertainty quantification. In this talk, we give an overview in numerical techniques in biomechanics and cardiology, including contact problems, the electro-mechanical activation of the human heart, and fluid-structure interaction in heart valves. Contact:
Rolf Krause has has studied Mathematics in Berlin and did his PhD in Stuttgart and Berlin. In 2003, he became Professor for Scientific Computing at the University of Bonn and moved in 2009 to USI in Lugano as founding director of the ICS, the Institute of Computational Science of USI. He is working in the areas finite element methods, non-linear domain decomposition and multigrid methods, and parallel in time methods, with applications in geo-mechanics, cardiac and biomechanics.