|Code:|| MOX 81|
|Title:|| Influence of boundary conditions on fluid dynamics in models of the cardiovascular system: a multiscale approach applied to the carotid bifurcation|
|Date:|| Monday 6th March 2006|
|Author(s) :|| Balossino, R., Pennati, G.; Migliavacca, F.; Formaggia, L.; Veneziani, A.; Tuveri, M.; Dubini, G.|
This work aims at addressing an important problem in the simulation of detailed 3D hemodynamic models of vascular districts
with complex anatomy. Namely, to define appropriate boundary conditions accounting for both local as well as global effects.
The approach devised in this work is based on a multiscale model, where the Navier-Stokes
equations for the district of interest are coupled to a non-linear system of ordinary differential equations which
describes the global circulatory system as a lumped parameter network. The multiscale approach is applied to three 3D models
of a carotid bifurcation which differ only in the severity of a stenosis in the internal carotid artery. The results of the
multiscale simulations are compared to those obtained by two stand-alone models of the carotid bifurcation, which differ in
the adopted strategy in prescribing the boundary conditions.
Significant differences are found in the results between the multiscale and the stand-alone models in
terms of flows, pressures and wall shear stresses distribution in the 3D domain.
The capability to numerically predict the hemodynamic changes due to the presence of a stenosis is highly
dependent on the availability of correct boundary conditions. The geometrical multiscale approach offers a logical and
proper alternative to the use of measured data to prescribe realistic boundary conditions and predict new hemodynamic scenarios.